A randomized controlled trial (RCT) is a study type that usually has at least two groups with one group receiving an "intervention" and the other group receiving a "placebo".
The intervention is the treatment that is being tested, while the placebo is an inactive substance that looks like the intervention. The groups are randomly assigned to receive either the intervention or the placebo. This means that each participant has an equal chance of being assigned to either group.
RCTs are considered to be the gold standard for medical research. This is because they are the best way to determine whether an intervention is effective. By randomly assigning participants to groups, RCTs help to ensure that the results are not due to chance.
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the nurse is preparing to administer penicillin g intramuscularly to a child. the child’s parents ask why the drug cannot be given in an oral liquid form. what is the nurse’s reply?
The nurse's reply while administering penicillin G intramuscularly to a child would be: d. "This drug would be inactivated by enzymes in the stomach."
Penicillin G is a type of antibiotic medication that is commonly used to treat bacterial infections. It is effective against a wide range of bacteria, including streptococci, staphylococci, and certain gram-negative organisms.
When medications are taken orally, they go through the digestive system, which includes the stomach. The stomach contains enzymes and acids that help break down and digest food. However, these enzymes and acids can also affect certain medications, including penicillin G.
If penicillin G were given in an oral liquid form and ingested, it would encounter the enzymes in the stomach, which would lead to its inactivation. The enzymes would break down the penicillin G molecule, rendering it ineffective and unable to exert its antimicrobial effects. This is why it is not administered orally.
To ensure that penicillin G is properly absorbed and reaches therapeutic levels in the bloodstream, it needs to be administered via alternative routes such as intramuscular (IM) or intravenous (IV) administration. By bypassing the digestive system and entering the bloodstream directly, the medication can reach its intended target and provide the desired therapeutic effect.
The complete question is:
The nurse is preparing to administer penicillin G intramuscularly to a child. The child’s parents ask why the drug cannot be given in an oral liquid form. What is the nurse’s reply?
a. “This drug causes severe gastric upset if givenorally.”
b. “This drug has a narrow therapeutic range, and the dose must be tightly controlled.”
c. “This drug is absorbed much too quickly in anoral form.”
d. “This drug would be inactivated by enzymes in the stomach.”
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